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Antimicrobial Resistance (AMR) Research Group

About us

About us

Antimicrobial Resistance (AMR) Research Group was created in 2023 to support research at Middlesex University that address the major public health problem of AMR, which comes in line with the UNSDGS of Good Health and Wellbeing and the Middlesex University Theme of Health and Wellbeing. The research activities led by AMR@É«ÖÐÉ«µ¼º½ also alligns with REF 2029 Units of Assessment (UoA), Main panel A: Medicine, Health and Life Sciences (1. Clinical Medicine, 2. Public Health, Health Services and Primary Care, and 5. Biological Sciences). 

together with Dr Enas Newire (Organiser) started and are co-leading this group, which supports 12 academics and includes technicians and research student working in multidiscipline research projects such as microbiology, molecular biology, bioinformatics, evolutionary biology, environmental biology, medicinal chemistry, chemistry, mathematical modelling, bio-analytical science and biophysics.  

At Middlesex University, we are committed to performing high-quality AMR research to understand and provide possible targeted solutions. Thus, we perform a full spectrum of AMR research excellence with our collaborators in academia, government and industry.  

AMR@É«ÖÐÉ«µ¼º½ currently supports therapeutic and diagnostic research projects investigations in the following areas:  

  • AMR Diagnostics 
  • Anti-plasmid approaches 
  • Efflux-pump investigations 
  • New antimicrobials 
  • Biofilm formation 

 

 

Projects

Projects

Ongoing Projects: 

  • Raise Awareness of AMR – WAAW Champion Award, Microbiology Sociaty.  
  • Led by Dr Enas Newire and Dr Blessing Oyedemi Mbaebie. 
  • Novel Anti-plasmid approaches (repurposing antimicrobials and novel CRISPR-Cas systems), University of Liverpool ECR and Pump Priming Awards. 
  • Led by Dr Enas Newire 
  • Efflux-pump investigations 

Shah, A., Shah, H., Duncan, L. and Ward, M. 2023. Diversity, transmission and selective pressure on the proteome of Pseudomonas aeruginosa. in: Shah, H., Gharbia, S., Shah, A., Tranfield, E. and Clive, T. (ed.) Microbiological Identification using MALDI-TOF and Tandem Mass Spectrometry Industrial and Environmental Applications Wiley. pp. 183-201

Parmar, A., Lakshminarayanan, R., Iyer, A., Goh, E.T.L., To, T.Y., Yam, J.K.H., Yang, L., Newire, E., Robertson, M.C., Prior, S.H., Breukink, E., Madder, M. and Singh, I. 2023. Development of teixobactin analogues containing hydrophobic, non-proteogenic amino acids that are highly potent against multidrug-resistant bacteria and biofilms. European Journal of Medicinal Chemistry. 261. 

Russo, C. and Purchase, D. 2023. Application of MALDI-TOF MS in bioremediation and environmental research. in: Shah, H.N., Gharbia, S.E., Shah, A., Tranfield, E.Y. and Thompson, K.C. (ed.) Microbiological Identification using MALDI-TOF and Tandem Mass Spectrometry: Industrial and Environmental Applications Wiley. pp. 255-282

 

Shah, H.N., Gharbia, S.E., Shah, A., Tranfield, E.Y. and Thompson, K.C. (ed.) 2023. Microbiological identification using MALDI-TOF and tandem mass spectrometry: industrial and environmental applications. W¾±±ô±ð²â. 

 

Raptakis, E, Shah, A., Gharbia, S.E., Shah, L.M.N, Francese, S., Tranfield, E.Y., Duncan, L. and Shah, H.N. 2023. Progress in the microbiological applications of mass spectrometry: From electron impact to soft ionization techniques, MALDI-TOF MS and beyond. in: Shah, H.N., Gharbia, S.E., Shah, A., Tranfield, E.Y. and Thompson, K.C. (ed.) Microbiological Identification using MALDI-TOF and Tandem Mass Spectrometry: Industrial and Environmental Applications Wiley. pp. 1-44 

 

Tripathi, S., Purchase, D., Govarthanan, M., Chandra, R. and Yadav, S. 2023. Regulatory and innovative mechanisms of bacterial quorum sensing-mediated pathogenicity: a review. Environmental Monitoring and Assessment. 195 (1).  

 

Scioli, G., Marinaccio, L., Bauer, M., Kamysz, W., Parmar, A., Newire, E., Singh, I., Stefanucci, A. and Mollica, A. 2023. New teixobactin analogues with a total lactam ring. ACS Medicinal Chemistry Letters. 14 (12), pp. 1603-1892.   

 

Rudra, B., Duncan, L., Shah, A., Shah, H. and Gupta, R. 2022. Phylogenomic and comparative genomic studies robustly demarcate two distinct clades of Pseudomonas aeruginosa strains: proposal to transfer the strains from an outlier clade to a novel species Pseudomonas paraeruginosa sp. nov. International Journal of Systematic and Evolutionary Microbiology. 72 (11), pp. 1-15.   

 

Vassallo, A., Kett, S., Purchase, D. and Marvasi, M. 2022. The bacterial urban resistome: recent advances. Antibiotics. 11 (4), pp. 1-17.

 

Marvasi, M., Casillas, L., Vassallo, A. and Purchase, D. 2021. Educational activities for students and citizens supporting the One-Health approach on antimicrobial resistance. Antibiotics. 10 (12).  

 

Vassallo, A., Kett, S., Purchase, D. and Marvasi, M. 2021. Antibiotic-resistant genes and bacteria as evolving contaminants of emerging concerns (e-CEC): is it time to include evolution in risk assessment? Antibiotics. 10 (9), pp. 1-11.  

 

Yagnik, D., Ward, M. and Shah, A. 2021. Antibacterial apple cider vinegar eradicates methicillin resistant Staphylococcus aureus and resistant Escherichia coli. Scientific Reports. 11 (1), pp. 1-7.   

 

Newire, E., Aydin, A., Juma, S., Enne, V. and Roberts, A. 2020. Identification of a Type IV-A CRISPR-Cas system located exclusively on IncHI1B/IncFIB plasmids in Enterobacteriaceae. Frontiers in Microbiology. 11.   

 

Hubbard, A.T.M., Newire, E., Botelho, J., Reiné, J., Wright, E., Murphy, E.A., Hutton, W. and Roberts, A.P. 2020. Isolation of an antimicrobial-resistant, biofilm-forming, Klebsiella grimontii isolate from a reusable water bottle. MicrobiologyOpen. 9 (6), pp. 1128-1134.   

 

Brouwer, M.S.M., Goodman, R.N., Kant, A., Newire, E., Roberts, A.P. and Veldman, K.T. 2020. Mobile colistin resistance gene mcr-1 detected on an IncI1 plasmid in Escherichia coli from meat. Journal of Global Antimicrobial Resistance. 23, pp. 145-148.   

 

Shah, H., Shah, A., Belgacem, O., Ward, M., Dekio, I., Selami, L., Duncan, L., Bruce, K., Xu, Z., Mkrtchyan, H., Cave, R., Shah, L. and Gharbia, S. 2020. MALDI TOF MS and currently related proteomic technologies in reconciling bacterial systematics. in: Bridge, P., Smith, D. and Stackebrandt, E. (ed.) Trends in the Systematics of Bacteria and Fungi Wallingford, UK CAB International. pp. 93-118 

 

Serafim, V., Shah, A., Licker, M., Horhat, F., Vulpie, S., Musuroi, C. and Muntean, D. 2020. Detection of extended-spectrum β-lactamase and carbapenemase activity in Gram-negative bacilli using liquid chromatography - tandem mass spectrometry. Infection and Drug Resistance. 13, pp. 4021-4029.   

 

Maruzani, R., Pathak, A., Ward, M., Serafim, V., Pantoja Munoz, L., Shah, A. and Marvasi, M. 2020. Antibiotic selective pressure in microcosms: pollution influences the persistence of multidrug resistant Shigella flexneri 2a YSH6000 strain in polluted river water samples. Environmental Technology and Innovation. 19.   

 

Singh, A., Zhao, K., Bell, C. and Shah, A. 2020. Effect of Berberine on in vitro metabolism of Sulfonylureas: a herb-drug interactions study. Rapid Communications in Mass Spectrometry. 34 (S4), pp. 1-12.   

 

Henríquez, T., Salazar, J., Marvasi, M., Shah, A., Corsini, G. and Toro, C. 2020. SRL pathogenicity island contributes to the metabolism of D-aspartate via an aspartate racemase in Shigella flexneri YSH6000. PLoS ONE. 15 (1), pp. 1-14.   

 

Xu, Z., Chen, J., Vougas, K., Shah, A., Shah, H., Misra, R. and Mkrtchyan, H. 2020. Comparative proteomic profiling of methicillin-susceptible and resistant Staphylococcus aureus. Proteomics. 20 (2), pp. 1-6.   

 

Marano, R., Fernandes, T., Manaia, C., Nunes, O., Morrison, D., Berendonk, T., Kreuzinger, N., Telson, T., Corno, G., Fatta-Kassinos, D., Merlin, C., Topp, E., Jurkevitch, E., Henn, L., Scott, A., Heß, S., Slipko, K., Laht, M., Kisand, V., Di Cesare, A., Karaolia, P., Michael, S., Petre, A., Rosal, R., Pruden, A., Riquelme, V., Agüera, A., Esteban, B., Luczkiewicz, A., Kalinowska, A., Leonard, A., Gaze, W., Adegoke, A., Stenstrom, T., Pollice, A., Salerno, C., Schwermer, C., Krzeminski, P., Guilloteau, H., Donner, E., Drigo, B., Libralato, G., Guida, M., Bürgmann, H., Beck, K., Garelick, H., Tacão, M., Henriques, I., Martínez-Alcalá, I., Guillén-Navarro, J., Popowska, M., Piotrowska, M., Quintela-Baluja, M., Bunce, J., Polo-López, M., Nahim-Granados, S., Pons, M., Milakovic, M., Udikovic-Kolic, N., Ory, J., Ousmane, T., Caballero, P., Oliver, A., Rodriguez-Mozaz, S., Balcazar, J., Jäger, T., Schwartz, T., Yang, Y., Zou, S., Lee, Y., Yoon, Y., Herzog, B., Mayrhofer, H., Prakash, O., Nimonkar, Y., Heath, E., Baraniak, A., Abreu-Silva, J., Choudhury, M., Pantoja Munoz, L., Krizanovic, S., Brunetti, G., Maile-Moskowitz, A., Brown, C. and Cytryn, E. 2020. A global multinational survey of cefotaxime-resistant coliforms in urban wastewater treatment plants. Environment International. 144, pp. 1-11.  

 

Collaborations

Collaborations

Members of the research group have wide research collaborations with University College London, Kings College London, Liverpool School of Tropical Medicine, University of Liverpool, University of Birmingham, MicrobesNG, Microbiology Society, Public Health England, Applied Microbiology International and The American Society for Microbiology.  

Our staff
Get in touch

Get in touch

Please, send inquiries to 

Dr Enas Newire e.newire@mdx.ac.uk , Dr Ajit Shah a.j.shah@mdx.ac.uk

AMR Research Group email:amr@mdx.ac.uk

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